8STG: Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations

PDB ID: 8STGDownload
MMDB ID: 237021
PDB Deposition Date: 2023/5/10
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.79  Å
Source Organism:
Similar Structures:
Biological Unit for 8STG: monomeric; determined by author
Molecular Components in 8STG
Label Count Molecule
Protein (1 molecule)
1
Fibroblast Growth Factor Receptor 2
(Gene symbol: FGFR2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-{4-[(5P)-4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}-2-methylpropanamideN-{4-[(5P)-4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}-2-methylpropanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303