8SS9: Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state)

PDB ID: 8SS9Download
MMDB ID: 235248
PDB Deposition Date: 2023/5/8
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 2.72  Å
Source Organism:
Similar Structures:
Biological Unit for 8SS9: tetrameric; determined by author
Molecular Components in 8SS9
Label Count Molecule
Proteins (4 molecules)
4
Glutamate Receptor 2, Voltage-dependent Calcium Channel Gamma-5 Subunit Chimera
(Gene symbol: Gria2)
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
4
2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile
2
4
{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
3
14
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
4
2
CHOLESTEROLCHOLESTEROL
5
2
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303