8SS3: Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)

PDB ID: 8SS3Download
MMDB ID: 235242
PDB Deposition Date: 2023/5/8
Updated in MMDB: 2023/11
Experimental Method:
electron microscopy
Resolution: 3.21  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 8SS3: hexameric; determined by author
Molecular Components in 8SS3
Label Count Molecule
Proteins (6 molecules)
4
Glutamate Receptor 2, Voltage-dependent Calcium Channel Gamma-5 Subunit Chimera
Molecule annotation
2
Protein Cornichon Homolog 2
Molecule annotation
Chemicals and Non-standard biopolymers (65 molecules)
1
4
{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
2
50
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
3
4
CHOLESTEROLCHOLESTEROL
4
6
DigitoninDigitonin
5
1
SPERMIDINESPERMIDINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303