8SMC: Cryo-EM structure of LRRK2 bound with type-I inhibitor DNL201

PDB ID: 8SMCDownload
MMDB ID: 240888
PDB Deposition Date: 2023/4/26
Updated in MMDB: 2024/01
Experimental Method:
electron microscopy
Resolution: 4.02  Å
Source Organism:
Similar Structures:
Biological Unit for 8SMC: monomeric; determined by author
Molecular Components in 8SMC
Label Count Molecule
Protein (1 molecule)
1
Non-specific Serine/threonine Protein Kinase
(Gene symbol: LRRK2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
2
1
2-methyl-2-(3-methyl-4-{[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1H-pyrazol-1-yl)propanenitrile2-methyl-2-(3-methyl-4-{[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1H-pyrazol-1-yl)propanenitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303