8SL9: Crystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73

PDB ID: 8SL9Download
MMDB ID: 246144
PDB Deposition Date: 2023/4/21
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 1.4  Å
Source Organism:
Similar Structures:
Biological Unit for 8SL9: monomeric; determined by author and by software (PISA)
Molecular Components in 8SL9
Label Count Molecule
Protein (1 molecule)
1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine Pyrophosphokinase
(Gene symbol: folK)
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
1
5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine
2
22
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
3
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303