8SIW: Structure of Compound 5 bound to the CHK1 10-point mutant

PDB ID: 8SIWDownload
MMDB ID: 237577
PDB Deposition Date: 2023/4/17
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.877  Å
Source Organism:
Similar Structures:
Biological Unit for 8SIW: monomeric; determined by software (PISA)
Molecular Components in 8SIW
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Chk1
(Gene symbol: CHEK1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(1S,2S)-N-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)cyclopropane-1-carboxamide(1S,2S)-N-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)cyclopropane-1-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303