8SIV: Structure of Compound 2 bound to the CHK1 10-point mutant

PDB ID: 8SIVDownload
MMDB ID: 237576
PDB Deposition Date: 2023/4/17
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.759  Å
Source Organism:
Similar Structures:
Biological Unit for 8SIV: monomeric; determined by author and by software (PISA)
Molecular Components in 8SIV
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Chk1
(Gene symbol: CHEK1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)cyclopropanecarboxamideN-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)cyclopropanecarboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303