8SC8: Structure of PI3KG in complex with MTX-531

PDB ID: 8SC8Download
MMDB ID: 248190
PDB Deposition Date: 2023/4/5
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.687  Å
Source Organism:
Similar Structures:
Biological Unit for 8SC8: monomeric; determined by author
Molecular Components in 8SC8
Label Count Molecule
Protein (1 molecule)
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Gamma Isoform
(Gene symbol: PIK3CG)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
5
SULFATE IONSULFATE ION
2
1
N-[(5P)-2-chloro-5-(4-{[(1R)-1-phenylethyl]amino}quinazolin-6-yl)pyridin-3-yl]methanesulfonamideN-[(5P)-2-chloro-5-(4-{[(1R)-1-phenylethyl]amino}quinazolin-6-yl)pyridin-3-yl]methanesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303