8S65: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii compounds: crystal structure, biochemical characterization and biological evaluation of inhibitors

PDB ID: 8S65Download
MMDB ID: 251251
PDB Deposition Date: 2024/2/26
Updated in MMDB: 2024/09
Experimental Method:
x-ray diffraction; solution scattering
Resolution: 2.56  Å
Source Organism:
Similar Structures:
Biological Unit for 8S65: monomeric; determined by author
Molecular Components in 8S65
Label Count Molecule
Protein (1 molecule)
1
1-deoxy-d-xylulose-5-phosphate Reductoisomerase
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
1
3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID
3
1
CHLORIDE IONCHLORIDE ION
4
3
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303