8RQC: Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2

PDB ID: 8RQCDownload
MMDB ID: 252643
PDB Deposition Date: 2024/1/17
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
Similar Structures:
Biological Unit for 8RQC: tetrameric; determined by author and by software
Molecular Components in 8RQC
Label Count Molecule
Proteins (4 molecules)
2
Protein Cereblon
(Gene symbol: CRBN)
Molecule annotation
2
DNA-binding Protein Ikaros
(Gene symbol: IKZF1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
4
ZINC IONZINC ION
2
2
MezigdomideMezigdomide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303