8RQ9: Crystal structure of PROTAC CFT-1297 in complex with CRBN-midi and BRD4(BD2)

PDB ID: 8RQ9Download
MMDB ID: 252641
PDB Deposition Date: 2024/1/17
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 2.91  Å
Source Organism:
Similar Structures:
Biological Unit for 8RQ9: dimeric; determined by author
Molecular Components in 8RQ9
Label Count Molecule
Proteins (2 molecules)
1
Protein Cereblon
(Gene symbol: CRBN)
Molecule annotation
1
Bromodomain-containing Protein 4
(Gene symbol: BRD4)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
Unknown
2
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303