8R8D: Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer)

PDB ID: 8R8DDownload
MMDB ID: 239832
PDB Deposition Date: 2023/11/29
Updated in MMDB: 2023/12
Experimental Method:
electron microscopy
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8R8D: hexameric; determined by author and by software
Molecular Components in 8R8D
Label Count Molecule
Proteins (6 molecules)
2
Coagulation Factor XII
(Gene symbol: F12)
Molecule annotation
2
Garadacimab Heavy Chain Variable Region
Molecule annotation
2
Garadacimab Light Chain Variable Region
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
4
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
beta-D-mannopyranosebeta-D-mannopyranose
3
4
alpha-D-mannopyranosealpha-D-mannopyranose
4
2
alpha-L-fucopyranosealpha-L-fucopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303