8R7V: MutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form

PDB ID: 8R7VDownload
MMDB ID: 254121
PDB Deposition Date: 2023/11/27
Updated in MMDB: 2024/11
Experimental Method:
electron microscopy
Resolution: 3.12  Å
Source Organism:
Similar Structures:
Biological Unit for 8R7V: tetrameric; determined by author and by software (PISA)
Molecular Components in 8R7V
Label Count Molecule
Proteins (2 molecules)
1
DNA Mismatch Repair Protein Msh2
(Gene symbol: MSH2)
Molecule annotation
1
DNA Mismatch Repair Protein Msh3
(Gene symbol: MSH3)
Molecule annotation
Nucleotides(2 molecules)
1
DNA_61bp_complement_rev
Molecule annotation
1
DNA_61bp_cag2_loop_fwd
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
MAGNESIUM IONMAGNESIUM ION
2
1
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
3
1
~{N}-[3-[[2-[[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide~{N}-[3-[[2-[[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide
4
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303