8R62: Solution structure of Risdiplam bound to the RNA duplex formed upon 5'-splice site recognition

PDB ID: 8R62Download
MMDB ID: 243710
PDB Deposition Date: 2023/11/20
Updated in MMDB: 2024/05
Experimental Method:
solution nmr
Source Organism:
Biological Unit for 8R62: dimeric; determined by author and by software
Molecular Components in 8R62
Label Count Molecule
Nucleotides(2 molecules)
1
RNA (5'-r(*ap*up*ap*cp*(psu)p*(psu)p*ap*cp*cp*up*g)-3')
Molecule annotation
1
RNA (5'-r(p*gp*gp*ap*gp*up*ap*ap*gp*up*cp*u)-3')
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-1~{H}-pyrido[1,2-a]pyrimidin-4-one7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-1~{H}-pyrido[1,2-a]pyrimidin-4-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303