8QTH: Crystal structure of CBL-b in complex with an allosteric inhibitor (compound 8)

PDB ID: 8QTHDownload
MMDB ID: 241085
PDB Deposition Date: 2023/10/12
Updated in MMDB: 2024/02
Experimental Method:
x-ray diffraction
Resolution: 2.198  Å
Source Organism:
Similar Structures:
Biological Unit for 8QTH: monomeric; determined by author and by software (PISA)
Molecular Components in 8QTH
Label Count Molecule
Protein (1 molecule)
1
E3 Ubiquitin-protein Ligase Cbl-b
(Gene symbol: CBLB)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
1-methyl-5-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-3-(trifluoromethyl)-7H-pyrrolo[2,3-b]pyridin-6-one1-methyl-5-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-3-(trifluoromethyl)-7H-pyrrolo[2,3-b]pyridin-6-one
2
2
ZINC IONZINC ION
3
1
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303