8QOO: Crystal structure of human Sirt2 in complex with the peptide-based pseudo-inhibitor TNFn-4.1

PDB ID: 8QOODownload
MMDB ID: 253211
PDB Deposition Date: 2023/9/29
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 1.55  Å
Source Organism:
Similar Structures:
Biological Unit for 8QOO: dimeric; determined by author and by software (PISA)
Molecular Components in 8QOO
Label Count Molecule
Proteins (2 molecules)
1
Nad-dependent Protein Deacetylase Sirtuin-2
(Gene symbol: SIRT2)
Molecule annotation
1
Peptide-based Pseudo-inhibitor Tnfn-4.1
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
ZINC IONZINC ION
2
1
(R,R)-2,3-BUTANEDIOL(R,R)-2,3-BUTANEDIOL
3
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
(2S,3S)-3-dodecylsulfanyl-2-methyl-butanoic acid(2S,3S)-3-dodecylsulfanyl-2-methyl-butanoic acid
5
1
(2S,3R)-3-dodecylsulfanyl-2-methyl-butanoic acid(2S,3R)-3-dodecylsulfanyl-2-methyl-butanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303