8QNG: Crystal structure of the E3 ubiquitin ligase Cbl-b with an allosteric inhibitor (benzodiazepine HTS hit compound 1)

PDB ID: 8QNGDownload
MMDB ID: 238847
PDB Deposition Date: 2023/9/26
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.197  Å
Source Organism:
Similar Structures:
Biological Unit for 8QNG: monomeric; determined by author and by software
Molecular Components in 8QNG
Label Count Molecule
Protein (1 molecule)
1
E3 Ubiquitin-protein Ligase Cbl-b
(Gene symbol: CBLB)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
2-(morpholin-4-ylmethyl)-~{N}-[(3~{S})-2-oxidanylidene-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]benzamide2-(morpholin-4-ylmethyl)-~{N}-[(3~{S})-2-oxidanylidene-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]benzamide
2
2
ZINC IONZINC ION
3
1
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303