8QKB: Crystal structure of human cathepsin L in complex with the vinyl sulfone inhibitor K777

PDB ID: 8QKBDownload
MMDB ID: 236213
PDB Deposition Date: 2023/9/14
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8QKB: tetrameric; determined by author and by software (PISA)
Molecular Components in 8QKB
Label Count Molecule
Proteins (4 molecules)
4
Cathepsin L
(Gene symbol: CTSL)
Molecule annotation
Chemicals and Non-standard biopolymers (31 molecules)
1
4
NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDENALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE
2
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
3
12
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
5
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
5
6
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
6
3
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303