8QJ7: Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1

PDB ID: 8QJ7Download
MMDB ID: 243053
PDB Deposition Date: 2023/9/12
Updated in MMDB: 2025/07
Experimental Method:
electron microscopy
Resolution: 3.07  Å
Source Organism:
Similar Structures:
Biological Unit for 8QJ7: tetrameric; determined by author and by software
Molecular Components in 8QJ7
Label Count Molecule
Proteins (4 molecules)
1
DNA Primase Small Subunit
(Gene symbol: PRIM1)
Molecule annotation
1
DNA Polymerase Alpha Catalytic Subunit
(Gene symbol: POLA1)
Molecule annotation
1
DNA Polymerase Alpha Subunit B
(Gene symbol: POLA2)
Molecule annotation
1
DNA Primase Large Subunit
(Gene symbol: PRIM2)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
3
ZINC IONZINC ION
2
2
MANGANESE (II) IONMANGANESE (II) ION
3
1
ADENOSINE-5'-TRIPHOSPHATEADENOSINE-5'-TRIPHOSPHATE
4
1
IRON/SULFUR CLUSTERIRON/SULFUR CLUSTER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303