8Q8G: Crystal structure of HsRNMT complexed with inhibitor DDD1870799

PDB ID: 8Q8GDownload
MMDB ID: 251432
PDB Deposition Date: 2023/8/18
Updated in MMDB: 2024/09
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 8Q8G: dimeric; determined by author and by software
Molecular Components in 8Q8G
Label Count Molecule
Proteins (2 molecules)
2
mRNA CAP Guanine-n7 Methyltransferase
(Gene symbol: RNMT)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
2
S-ADENOSYL-L-HOMOCYSTEINES-ADENOSYL-L-HOMOCYSTEINE
2
2
2-(4-fluorophenyl)-1-[(3~{S})-3-(6-oxidanyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl]ethanone2-(4-fluorophenyl)-1-[(3~{S})-3-(6-oxidanyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl]ethanone
3
3
SULFATE IONSULFATE ION
4
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303