8Q7R: Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide

PDB ID: 8Q7RDownload
MMDB ID: 243046
PDB Deposition Date: 2023/8/16
Updated in MMDB: 2025/07
Experimental Method:
electron microscopy
Resolution: 3.71  Å
Source Organism:
Similar Structures:
Biological Unit for 8Q7R: octameric; determined by author
Molecular Components in 8Q7R
Label Count Molecule
Proteins (8 molecules)
1
Cullin-2
(Gene symbol: CUL2)
Molecule annotation
1
Protein Fem-1 Homolog C
(Gene symbol: FEM1C)
Molecule annotation
1
Ubiquitin
(Gene symbol: UBC)
Molecule annotation
1
Nucleotide Exchange Factor Sil1
(Gene symbol: SIL1)
Molecule annotation
1
Ubiquitin-conjugating Enzyme E2 R2
(Gene symbol: UBE2R2)
Molecule annotation
1
Elongin-c
(Gene symbol: ELOC)
Molecule annotation
1
Elongin-b
(Gene symbol: ELOB)
Molecule annotation
1
E3 Ubiquitin-protein Ligase Rbx1
(Gene symbol: RBX1)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
5-azanyl-1-oxidanyl-pentan-2-one5-azanyl-1-oxidanyl-pentan-2-one
2
3
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303