8PWH: Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex

PDB ID: 8PWHDownload
MMDB ID: 243044
PDB Deposition Date: 2023/7/20
Updated in MMDB: 2024/05
Experimental Method:
electron microscopy
Resolution: 3.17  Å
Source Organism:
Similar Structures:
Biological Unit for 8PWH: pentameric; determined by author and by software (PISA)
Molecular Components in 8PWH
Label Count Molecule
Proteins (5 molecules)
1
Trastuzumab FAB Light Chain
Molecule annotation
1
Trastuzumab FAB Heavy Chain
Molecule annotation
1
Pertuzumab FAB Light Chain
Molecule annotation
1
Pertuzumab FAB Heavy Chain
Molecule annotation
1
Receptor Tyrosine-protein Kinase Erbb-2
(Gene symbol: ERBB2)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
7
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
beta-D-mannopyranosebeta-D-mannopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303