8PWE: Crystal structure of VDR complex with Novel Des-C-Ring and Aromatic-D-Ring analog 3a

PDB ID: 8PWEDownload
MMDB ID: 250665
PDB Deposition Date: 2023/7/20
Updated in MMDB: 2024/08
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Homo sapiens▼
Similar Structures:
Biological Unit for 8PWE: tetrameric; determined by author and by software (PISA)
Molecular Components in 8PWE
Label Count Molecule
Proteins (4 molecules)
2
Vitamin D3 Receptor a
Molecule annotation
2
Nuclear Receptor Coactivator 2
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
ACETATE IONACETATE ION
2
2
(1~{R},3~{S},5~{Z})-4-methylidene-5-[(~{E})-3-[3-(6-methyl-6-oxidanyl-hept-3-ynyl)phenyl]pent-2-enylidene]cyclohexane-1,3-diol(1~{R},3~{S},5~{Z})-4-methylidene-5-[(~{E})-3-[3-(6-methyl-6-oxidanyl-hept-3-ynyl)phenyl]pent-2-enylidene]cyclohexane-1,3-diol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303