8PRX: Crystal structure of human cathepsin L after reaction with the bound ketoamide inhibitor 13b

PDB ID: 8PRXDownload
MMDB ID: 234522
PDB Deposition Date: 2023/7/12
Updated in MMDB: 2023/08
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 8PRX: tetrameric; determined by author and by software
Molecular Components in 8PRX
Label Count Molecule
Proteins (4 molecules)
4
Cathepsin L
(Gene symbol: CTSL)
Molecule annotation
Chemicals and Non-standard biopolymers (37 molecules)
1
4
~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{S})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{S})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate
2
11
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
8
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
4
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
5
10
1,2-ETHANEDIOL1,2-ETHANEDIOL
6
3
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303