8PQE: c-KIT kinase domain in complex with avapritinib derivative 11

PDB ID: 8PQEDownload
MMDB ID: 240604
PDB Deposition Date: 2023/7/11
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 8PQE: monomeric; determined by author
Molecular Components in 8PQE
Label Count Molecule
Protein (1 molecule)
1
Mast/stem Cell Growth Factor Receptor KIT
(Gene symbol: KIT)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
1
~{N}-[(1~{S})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]prop-2-enamide~{N}-[(1~{S})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]prop-2-enamide
3
1
BROMIDE IONBROMIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303