8PPZ: Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR

PDB ID: 8PPZDownload
MMDB ID: 233969
PDB Deposition Date: 2023
Updated in MMDB: 2023/08
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Similar Structures:
Biological Unit for 8PPZ: dimeric; determined by author and by software (PISA)
Molecular Components in 8PPZ
Label Count Molecule
Proteins (2 molecules)
1
Peptidyl-prolyl Cis-trans Isomerase Fkbp1a
(Gene symbol: FKBP1A)
Molecule annotation
1
Serine/threonine-protein Kinase Mtor
(Gene symbol: MTOR)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-[(~{E})-2-(2-chlorophenyl)ethenyl]-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-[(~{E})-2-(2-chlorophenyl)ethenyl]-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one
2
4
CALCIUM IONCALCIUM ION
3
1
ACETATE IONACETATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303