8POK: Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid environment

PDB ID: 8POKDownload
MMDB ID: 243678
PDB Deposition Date: 2023/7/5
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.4  Å
Source Organism:
Lama glama▼
Similar Structures:
Biological Unit for 8POK: pentameric; determined by author
Molecular Components in 8POK
Label Count Molecule
Proteins (5 molecules)
1
Histamine H2 Receptor
Molecule annotation
1
Isoform Gnas-2 of Guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Nanobody35
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
HISTAMINEHISTAMINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303