8PEC: OXA-48_Q5-CAZ. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution

PDB ID: 8PECDownload
MMDB ID: 242643
PDB Deposition Date: 2023/6/13
Updated in MMDB: 2025/12
Experimental Method:
x-ray diffraction
Resolution: 2.66  Å
Source Organism:
Similar Structures:
Biological Unit for 8PEC: dimeric; determined by author and by software (PISA)
Molecular Components in 8PEC
Label Count Molecule
Proteins (2 molecules)
2
Beta-lactamase
(Gene symbol: bla)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium
2
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303