8PB1: Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement

PDB ID: 8PB1Download
MMDB ID: 242348
PDB Deposition Date: 2023/6/8
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.5  Å
Source Organism:
Similar Structures:
Biological Unit for 8PB1: tetrameric; determined by author
Molecular Components in 8PB1
Label Count Molecule
Proteins (4 molecules)
1
Interleukin-12 Subunit Alpha
(Gene symbol: Il12a)
Molecule annotation
1
Interleukin-12 Subunit Beta
(Gene symbol: Il12b)
Molecule annotation
1
Interleukin-12 Receptor Subunit Beta-1,death-associated Protein Kinase 1
(Gene symbol: DAPK1)
Molecule annotation
1
Interleukin-12 Receptor Subunit Beta-2,calmodulin-1
(Gene symbol: CALM1)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
6
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranosebeta-D-mannopyranose
3
1
alpha-D-mannopyranosealpha-D-mannopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303