8P81: Crystal structure of human Cdk12/Cyclin K in complex with inhibitor SR-4835

PDB ID: 8P81Download
MMDB ID: 238807
PDB Deposition Date: 2023/5/31
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.68  Å
Source Organism:
Similar Structures:
Biological Unit for 8P81: dimeric; determined by author and by software (PISA)
Molecular Components in 8P81
Label Count Molecule
Proteins (2 molecules)
1
Cyclin-dependent Kinase 12
(Gene symbol: CDK12)
Molecule annotation
1
Cyclin-k
(Gene symbol: CCNK)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303