8P7L: Cryo-EM structure of CDK7 subunit of CAK in complex with inhibitor LDC4297

PDB ID: 8P7LDownload
MMDB ID: 244294
PDB Deposition Date: 2023/5/30
Updated in MMDB: 2024/04
Experimental Method:
electron microscopy
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8P7L: dimeric; determined by author and by software (PISA)
Molecular Components in 8P7L
Label Count Molecule
Proteins (2 molecules)
1
Cdk-activating Kinase Assembly Factor Mat1
(Gene symbol: MNAT1)
Molecule annotation
1
Cyclin-dependent Kinase 7
(Gene symbol: CDK7)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-[(3S)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine2-[(3S)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303