8P71: Cryo-EM structure of CAK in complex with inhibitor ICEC0574

PDB ID: 8P71Download
MMDB ID: 244285
PDB Deposition Date: 2023/5/30
Updated in MMDB: 2024/04
Experimental Method:
electron microscopy
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 8P71: trimeric; determined by author and by software (PISA)
Molecular Components in 8P71
Label Count Molecule
Proteins (3 molecules)
1
Cdk-activating Kinase Assembly Factor Mat1
(Gene symbol: MNAT1)
Molecule annotation
1
Cyclin-h
(Gene symbol: CCNH)
Molecule annotation
1
Cyclin-dependent Kinase 7
(Gene symbol: CDK7)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(3R,4S)-4-[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]pyrrolidin-3-ol(3R,4S)-4-[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]pyrrolidin-3-ol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303