8P6Z: Cryo-EM structure of CAK in complex with inhibitor ICEC0510-R

PDB ID: 8P6ZDownload
MMDB ID: 244283
PDB Deposition Date: 2023/5/30
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8P6Z: trimeric; determined by author
Molecular Components in 8P6Z
Label Count Molecule
Proteins (3 molecules)
1
Cdk-activating Kinase Assembly Factor Mat1
(Gene symbol: MNAT1)
Molecule annotation
1
Cyclin-h
(Gene symbol: CCNH)
Molecule annotation
1
Cyclin-dependent Kinase 7
(Gene symbol: CDK7)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N7-(phenylmethyl)-3-propan-2-yl-N5-[(3R)-pyrrolidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamineN7-(phenylmethyl)-3-propan-2-yl-N5-[(3R)-pyrrolidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303