8P5K: Kinase domain of mutant human ULK1 in complex with compound MRT68921

PDB ID: 8P5KDownload
MMDB ID: 247863
PDB Deposition Date: 2023/5/24
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.209  Å
Source Organism:
Similar Structures:
Biological Unit for 8P5K: monomeric; determined by author
Molecular Components in 8P5K
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Ulk1
(Gene symbol: ULK1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
~{N}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{H}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide~{N}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{H}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
2
1
GLYCEROLGLYCEROL
3
2
MAGNESIUM IONMAGNESIUM ION
4
1
PHOSPHATE IONPHOSPHATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303