8P1W: Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with allosteric compound STL232591

PDB ID: 8P1WDownload
MMDB ID: 234885
PDB Deposition Date: 2023/5/12
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.15  Å
Source Organism:
Similar Structures:
Biological Unit for 8P1W: dimeric; determined by author
Molecular Components in 8P1W
Label Count Molecule
Proteins (2 molecules)
2
S-adenosylmethionine Synthase Isoform Type-2
(Gene symbol: MAT2A)
Molecule annotation
Chemicals and Non-standard biopolymers (22 molecules)
1
2
5'-DEOXY-5'-METHYLTHIOADENOSINE5'-DEOXY-5'-METHYLTHIOADENOSINE
2
2
ALPHA-AMINOBUTYRIC ACIDALPHA-AMINOBUTYRIC ACID
3
2
8-methoxy-1-(4-methoxyphenyl)-3-methyl-2-oxidanyl-[1]benzofuro[3,2-c]pyridine8-methoxy-1-(4-methoxyphenyl)-3-methyl-2-oxidanyl-[1]benzofuro[3,2-c]pyridine
4
6
CHLORIDE IONCHLORIDE ION
5
10
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303