8P1T: Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Z237451470

PDB ID: 8P1TDownload
MMDB ID: 234883
PDB Deposition Date: 2023/5/12
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 1.442  Å
Source Organism:
Similar Structures:
Biological Unit for 8P1T: dimeric; determined by author and by software (PISA)
Molecular Components in 8P1T
Label Count Molecule
Proteins (2 molecules)
2
S-adenosylmethionine Synthase Isoform Type-2
(Gene symbol: MAT2A)
Molecule annotation
Chemicals and Non-standard biopolymers (18 molecules)
1
2
S-ADENOSYLMETHIONINES-ADENOSYLMETHIONINE
2
2
6-cyclopropyl-~{N}-(1~{H}-indazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxamide6-cyclopropyl-~{N}-(1~{H}-indazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxamide
3
10
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
2
CHLORIDE IONCHLORIDE ION
5
2
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303