8P0T: CryoEM structure of 20S Trichomonas vaginalis proteasome in complex with proteasome inhibitor CP-17

PDB ID: 8P0TDownload
MMDB ID: 247224
PDB Deposition Date: 2023/5/10
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 2.65  Å
Source Organism:
Similar Structures:
Biological Unit for 8P0T: 28-meric; determined by author and by software (PISA)
Molecular Components in 8P0T
Label Count Molecule
Proteins (28 molecules)
2
Family T1, Proteasome Alpha Subunit, Threonine Peptidase
(Gene symbol: TVAG_267300)
Molecule annotation
2
Family T1, Proteasome Alpha Subunit, Threonine Peptidase
(Gene symbol: TVAG_103780)
Molecule annotation
2
Proteasome Subunit Alpha Type
(Gene symbol: TVAG_058050)
Molecule annotation
2
Proteasome Subunit Alpha Type
(Gene symbol: TVAG_340740)
Molecule annotation
2
Proteasome Subunit Alpha Type
(Gene symbol: TVAG_293540)
Molecule annotation
2
Family T1, Proteasome Alpha Subunit, Threonine Peptidase
(Gene symbol: TVAG_206040)
Molecule annotation
2
Family T1, Proteasome Alpha Subunit, Threonine Peptidase
(Gene symbol: TVAG_185200)
Molecule annotation
2
Proteasome Subunit Beta
(Gene symbol: TVAG_127250)
Molecule annotation
2
Proteasome Endopeptidase Complex
(Gene symbol: TVAG_231360)
Molecule annotation
2
Proteasome Subunit Beta
(Gene symbol: TVAG_286960)
Molecule annotation
2
Proteasome Subunit Beta
(Gene symbol: TVAG_403280)
Molecule annotation
2
Proteasome Subunit Beta
(Gene symbol: TVAG_013010)
Molecule annotation
2
Proteasome Subunit Beta
(Gene symbol: TVAG_152400)
Molecule annotation
2
Family T1, Proteasome Beta Subunit, Threonine Peptidase
(Gene symbol: TVAG_290960)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
N-[(2S)-1-[[(2S)-1-[[(1S)-1-[(2S,3R,5S,6R)-3-(hydroxymethyl)-5-methanoyl-2,3,6-trimethyl-morpholin-2-yl]-2-phenyl-ethyl]amino]-3-(1H-indol-3-yl)-1-oxidanylidene-propan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxidanylidene-propan-2-yl]hexanamideN-[(2S)-1-[[(2S)-1-[[(1S)-1-[(2S,3R,5S,6R)-3-(hydroxymethyl)-5-methanoyl-2,3,6-trimethyl-morpholin-2-yl]-2-phenyl-ethyl]amino]-3-(1H-indol-3-yl)-1-oxidanylidene-propan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxidanylidene-propan-2-yl]hexanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303