8OXG: Crystal structure of human methionine aminopeptidase-2 complexed with (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl N-(trans-4-aminocyclohexyl)carbamate

PDB ID: 8OXGDownload
MMDB ID: 245198
PDB Deposition Date: 2023/5/2
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 1.731  Å
Source Organism:
Similar Structures:
Biological Unit for 8OXG: dimeric; determined by author and by software (PISA)
Molecular Components in 8OXG
Label Count Molecule
Proteins (2 molecules)
2
Methionine Aminopeptidase 2
(Gene symbol: METAP2)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
[(1~{R},2~{S},3~{S},4~{R})-2-methoxy-4-methyl-3-[(2~{R},3~{S})-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-4-oxidanyl-cyclohexyl] ~{N}-(4-azanylcyclohexyl)carbamate[(1~{R},2~{S},3~{S},4~{R})-2-methoxy-4-methyl-3-[(2~{R},3~{S})-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-4-oxidanyl-cyclohexyl] ~{N}-(4-azanylcyclohexyl)carbamate
2
4
MANGANESE (II) IONMANGANESE (II) ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303