8OWZ: Crystal structure of human Sirt2 in complex with a triazole-based SirReal

PDB ID: 8OWZDownload
MMDB ID: 238541
PDB Deposition Date: 2023/4/28
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.65  Å
Source Organism:
Similar Structures:
Biological Unit for 8OWZ: monomeric; determined by author and by software (PISA)
Molecular Components in 8OWZ
Label Count Molecule
Protein (1 molecule)
1
Nad-dependent Protein Deacetylase Sirtuin-2
(Gene symbol: SIRT2)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
1
2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-[[3-[[1-(2-methoxyethyl)-1,2,3-triazol-4-yl]methoxy]phenyl]methyl]-1,3-thiazol-2-yl]ethanamide2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-[[3-[[1-(2-methoxyethyl)-1,2,3-triazol-4-yl]methoxy]phenyl]methyl]-1,3-thiazol-2-yl]ethanamide
2
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
4
2
(R,R)-2,3-BUTANEDIOL(R,R)-2,3-BUTANEDIOL
5
1
ZINC IONZINC ION
6
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303