8OUO: Human TPC2 in Complex with Antagonist (S)-SG-094

PDB ID: 8OUODownload
MMDB ID: 248135
PDB Deposition Date: 2023/4/24
Updated in MMDB: 2024/08
Experimental Method:
electron microscopy
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 8OUO: dimeric; determined by author and by software (PISA)
Molecular Components in 8OUO
Label Count Molecule
Proteins (2 molecules)
2
Two Pore Channel Protein 2
(Gene symbol: TPCN2)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
2
di-heneicosanoyl phosphatidyl cholinedi-heneicosanoyl phosphatidyl choline
2
3
2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside
3
1
(1S)-6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline(1S)-6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline
4
2
1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE
5
6
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303