8OHQ: Crystal structure of human heparanase in complex with competitive inhibitor derrived from siastatin B

PDB ID: 8OHQDownload
MMDB ID: 241056
PDB Deposition Date: 2023/3/21
Updated in MMDB: 2024/01
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 8OHQ: dimeric; determined by author
Molecular Components in 8OHQ
Label Count Molecule
Proteins (2 molecules)
1
Heparanase 50 KDA Subunit
(Gene symbol: HPSE)
Molecule annotation
1
Heparanase 8 KDA Subunit
(Gene symbol: HPSE)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
5
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
alpha-L-fucopyranosealpha-L-fucopyranose
3
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
3
CHLORIDE IONCHLORIDE ION
5
1
(3~{S},4~{S})-4,5,5-tris(oxidanyl)piperidine-3-carboxylic acid(3~{S},4~{S})-4,5,5-tris(oxidanyl)piperidine-3-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303