8K4S: CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P

PDB ID: 8K4SDownload
MMDB ID: 254494
PDB Deposition Date: 2023/7/20
Updated in MMDB: 2024/12
Experimental Method:
electron microscopy
Resolution: 2.9  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8K4S: pentameric; determined by author
Molecular Components in 8K4S
Label Count Molecule
Proteins (5 molecules)
1
Soluble Cytochrome B562,mas-related G-protein Coupled Receptor Member X4,green Fluorescent Protein
Molecule annotation
1
Gs-mini-gq Chimera
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Scfv16
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid(4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303