8K4F: DHODH in complex with compound A0

PDB ID: 8K4FDownload
MMDB ID: 247571
PDB Deposition Date: 2023/7/18
Updated in MMDB: 2024/06
Experimental Method:
x-ray diffraction
Resolution: 2.48  Å
Source Organism:
Similar Structures:
Biological Unit for 8K4F: dimeric; determined by author and by software (PISA)
Molecular Components in 8K4F
Label Count Molecule
Proteins (2 molecules)
2
Dihydroorotate Dehydrogenase (Quinone), Mitochondrial
(Gene symbol: DHODH)
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
6
SULFATE IONSULFATE ION
2
4
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
3
2
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
4
2
6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione
5
6
ACETATE IONACETATE ION
6
4
CHLORIDE IONCHLORIDE ION
7
2
5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303