8JVI: Structure of human TRPV4 with antagonist A2

PDB ID: 8JVIDownload
MMDB ID: 246419
PDB Deposition Date: 2023/6/28
Updated in MMDB: 2025/07
Experimental Method:
electron microscopy
Resolution: 3.21  Å
Source Organism:
Similar Structures:
Biological Unit for 8JVI: tetrameric; determined by author
Molecular Components in 8JVI
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily V Member 4,3c-gfp
(Gene symbol: TRPV4)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
[6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone[6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303