8JU6: Structure of human TRPV4 with antagonist GSK279

PDB ID: 8JU6Download
MMDB ID: 246418
PDB Deposition Date: 2023/6/24
Updated in MMDB: 2025/08
Experimental Method:
electron microscopy
Resolution: 3.45  Å
Source Organism:
Similar Structures:
Biological Unit for 8JU6: tetrameric; determined by author
Molecular Components in 8JU6
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily V Member 4,3c-gfp
(Gene symbol: TRPV4)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303