8JU5: Structure of human TRPV4 with antagonist A1

PDB ID: 8JU5Download
MMDB ID: 246417
PDB Deposition Date: 2023/6/24
Updated in MMDB: 2025/08
Experimental Method:
electron microscopy
Resolution: 3.74  Å
Source Organism:
Similar Structures:
Biological Unit for 8JU5: tetrameric; determined by author
Molecular Components in 8JU5
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily V Member 4,3c-gfp
(Gene symbol: TRPV4)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303