8JIU: Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GCGR-Gs complex

PDB ID: 8JIUDownload
MMDB ID: 235477
PDB Deposition Date: 2023/5/27
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 2.76  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8JIU: hexameric; determined by author
Molecular Components in 8JIU
Label Count Molecule
Proteins (6 molecules)
1
Guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short
Molecule annotation
1
Sar425899
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Nanobody 35
Molecule annotation
1
Glucagon Receptor
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-hexadecanoyl-L-glutamic acidN-hexadecanoyl-L-glutamic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303