8JF5: Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAS1440

PDB ID: 8JF5Download
MMDB ID: 247196
PDB Deposition Date: 2023/5/17
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 3.2  Å
Source Organism:
Similar Structures:
Biological Unit for 8JF5: dimeric; determined by author and by software (PISA)
Molecular Components in 8JF5
Label Count Molecule
Proteins (2 molecules)
1
Lysine-specific Histone Demethylase 1A
(Gene symbol: KDM1A)
Molecule annotation
1
Rest Corepressor 1
(Gene symbol: RCOR1)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
FLAVIN-ADENINE DINUCLEOTIDEFLAVIN-ADENINE DINUCLEOTIDE
2
2
GLYCEROLGLYCEROL
3
1
4-[5-[(3~{R})-3-azanylpyrrolidin-1-yl]carbonyl-2-[2-fluoranyl-4-(2-methyl-2-oxidanyl-propyl)phenyl]phenyl]-2-fluoranyl-benzenecarbonitrile4-[5-[(3~{R})-3-azanylpyrrolidin-1-yl]carbonyl-2-[2-fluoranyl-4-(2-methyl-2-oxidanyl-propyl)phenyl]phenyl]-2-fluoranyl-benzenecarbonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303