8JE7: Crystal Structure of Anopheles culicifacies Prolyl-tRNA Synthetase (AcPRS) in complex with two inhibitors (Halofuginone and L95)

PDB ID: 8JE7Download
MMDB ID: 255625
PDB Deposition Date: 2023/5/15
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.14  Å
Source Organism:
Similar Structures:
Biological Unit for 8JE7: dimeric; determined by author and by software (PISA)
Molecular Components in 8JE7
Label Count Molecule
Proteins (2 molecules)
2
Prolyl-trna Synthetase
Molecule annotation
Chemicals and Non-standard biopolymers (17 molecules)
1
2
ZINC IONZINC ION
2
2
7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one
3
2
~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide
4
4
BROMIDE IONBROMIDE ION
5
4
GLYCEROLGLYCEROL
6
3
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303