8JD5: Cryo-EM structure of Gi1-bound mGlu2-mGlu4 heterodimer

PDB ID: 8JD5Download
MMDB ID: 232008
PDB Deposition Date: 2023/5/12
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.6  Å
Source Organism:
Homo sapiens▼
Similar Structures:
Biological Unit for 8JD5: hexameric; determined by author
Molecular Components in 8JD5
Label Count Molecule
Proteins (6 molecules)
1
Metabotropic Glutamate Receptor 2
Molecule annotation
1
Metabotropic Glutamate Receptor 4
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Scfv
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
1
1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one
2
2
GLUTAMIC ACIDGLUTAMIC ACID
3
5
CHOLESTEROLCHOLESTEROL
4
1
DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINEDI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE
5
2
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
6
1
5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303